Pyridine, 2,4,6-trichloro- → 2,6-Dichloro-4-methoxypyridine

HRID 1360673

반응식

HRID 1360673 반응식
[Cl:1][C:2]1[CH:7]=[C:6](Cl)[CH:5]=[C:4]([Cl:9])[N:3]=1.C[O-].[Na+].[C:13](OCC)(=[O:15])C.O>CO>[Cl:1][C:2]1[CH:7]=[C:6]([O:15][CH3:13])[CH:5]=[C:4]([Cl:9])[N:3]=1

참가 물질

5

반응물 3

HCID 27665Pyridine, 2,4,6-trichloro-HCID 10942334Sodium MethoxideHCID 22728543Water ethylacetate

생성물 1

HCID 33199932,6-Dichloro-4-methoxypyridine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 2,4,6-trichloropyridine (4.5 g) in methanol was added sodium methoxide (25% in methanol, 6.8 mL) at room temperature. The mixture was stirred for 12 h then poured into ethyl acetate/water and separated. The organic layer was washed with water, brine and dried over magnesium sulfate. Upon evaporating, the residue was purified by crystallization (100% hexanes) to give title compound as solid (3.1 g).

후처리

  1. customseparated
  2. washThe organic layer was washed with water, brine
  3. dry with materialdried over magnesium sulfate
  4. customUpon evaporating
  5. customthe residue was purified by crystallization (100% hexanes)

출처 및 근거

ORD 기록
ord-f5b3f16c56ba46f48aa34f6b160730c0
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07879875B2

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