Water → 6H-thiazolo[5,4-e]indazol-2-amine

HRID 1360834

반응식

HRID 1360834 반응식
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[CH:5]2.[S-:11][C:12]#[N:13].[Na+].BrBr.O>C(O)(=O)C>[S:11]1[C:3]2[C:4]3[CH:5]=[N:6][NH:7][C:8]=3[CH:9]=[CH:10][C:2]=2[N:1]=[C:12]1[NH2:13]

참가 물질

6

반응물 4

HCID 962WaterHCID 24408BromineHCID 880121H-Indazol-5-amineHCID 516871Sodium thiocyanate

생성물 1

HCID 450776746H-thiazolo[5,4-e]indazol-2-amine수율 108.6%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

2.0 g (15 mmol) of 5-aminoindazole and 4.9 g (60.5 mmol) of sodium thiocyanate were suspended in 10 ml of acetic acid, and 2.4 g (15 mmol) of bromine was added dropwise to the suspension under ice-cooling. The reaction mixture was allowed to warm to room temperature, and it was stirred overnight. The reaction mixture was poured into water, and the resulting crystals were collected by filtration to give 3.1 g of 6H-pyrazolo[4′,3′:3,4]benzo[1,2-d]thiazol-2-ylamine.

후처리

  1. temperaturecooling
  2. filtrationthe resulting crystals were collected by filtration

출처 및 근거

ORD 기록
ord-a08db6a131d245279357b2eff5f3a1bc
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07879887B2

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