Sulfuric Acid → 4-nitro-6H-pyrazolo[4',3':3,4]benzo[1,2-d]thiazol-2-ylamine

HRID 1360835

반응식

HRID 1360835 반응식
[N+:1]([O-:4])([O-])=[O:2].[Na+].[S:6]1[C:10]2[C:11]3[CH:17]=[N:16][NH:15][C:12]=3[CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[NH2:18].S(=O)(=O)(O)O>>[N+:1]([C:14]1[C:9]2[N:8]=[C:7]([NH2:18])[S:6][C:10]=2[C:11]2[CH:17]=[N:16][NH:15][C:12]=2[CH:13]=1)([O-:4])=[O:2]

참가 물질

4

반응물 3

HCID 1118Sulfuric AcidHCID 24268Sodium NitrateHCID 450776746H-thiazolo[5,4-e]indazol-2-amine

생성물 1

HCID 579512644-nitro-6H-pyrazolo[4',3':3,4]benzo[1,2-d]thiazol-2-ylamine수율 68%

실험 절차

Under ice-cooling, 184 mg (2.17 mmol) of sodium nitrate was added to a mixture of 191 mg (1.01 mmol) of 6H-pyrazolo[4′,3′:3,4]benzo[1,2-d]thiazol-2-ylamine and 3 ml of concentrated sulfuric acid, and the mixture was stirred for 0.5 hours. The reaction mixture was poured onto ice, and the precipitated solid was collected by filtration, and then washed with water and methanol to give 160 mg (yield: 68%) of 4-nitro-6H-pyrazolo[4′,3′:3,4]benzo[1,2-d]thiazol-2-ylamine.

후처리

  1. temperatureUnder ice-cooling
  2. additionThe reaction mixture was poured onto ice
  3. filtrationthe precipitated solid was collected by filtration
  4. washwashed with water and methanol

출처 및 근거

ORD 기록
ord-0bed401fe72d48eebf2cae23634b86ec
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07879887B2

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