Thiazolidinedione → 5-(3,4-Dibromobenzylidene)thiazolidine-2,4-dione

HRID 1360986

반응식

HRID 1360986 반응식
[S:1]1[CH2:5][C:4](=[O:6])[NH:3][C:2]1=[O:7].[Br:8][C:9]1[CH:10]=[C:11]([CH:14]=[CH:15][C:16]=1[Br:17])[CH:12]=O.N1CCCCC1>C(O)(=O)C>[Br:8][C:9]1[CH:10]=[C:11]([CH:14]=[CH:15][C:16]=1[Br:17])[CH:12]=[C:5]1[S:1][C:2](=[O:7])[NH:3][C:4]1=[O:6]

참가 물질

5

반응물 3

HCID 5437ThiazolidinedioneHCID 8082PiperidineHCID 6220533,4-Dibromobenzaldehyde

생성물 1

HCID 765458665-(3,4-Dibromobenzylidene)thiazolidine-2,4-dione

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of thiazolidine-2,4-dione (90%, 65 mg, 0.5 mmol), 3,4-dibromobenzaldehyde (132 mg, 0.5 mmol), and piperidine (247 μL, 2.5 mmol) was shaken in acetic acid (2 mL) at 110° C. for 16 hours. After cooling, the mixture was concentrated to dryness in vacuo. The resulting crude product was shaken with water, centrifuged, and the supernatant was discarded. Subsequently the residue was shaken with ethanol, centrifuged, the supernatant was discarded and the residue was further evaporated to dryness to afford the title compound.

후처리

  1. temperatureAfter cooling
  2. concentrationthe mixture was concentrated to dryness in vacuo
  3. stirringSubsequently the residue was shaken with ethanol
  4. customthe residue was further evaporated to dryness

출처 및 근거

ORD 기록
ord-1368f77cd1ce4057b5c4f1e0728b3996
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07879893B2

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