Thiazolidinedione → HCID 76545899, 화합물

HRID 1360996노트

반응식

HRID 1360996 반응식
[S:1]1[CH2:5][C:4](=[O:6])[NH:3][C:2]1=[O:7].[CH:8]([C:10]1[CH:22]=[CH:21][C:13]([O:14][CH2:15][CH2:16][CH2:17][C:18]([OH:20])=[O:19])=[CH:12][CH:11]=1)=O.C([O-])(=O)C.[Na+]>C(O)(=O)C>[O:7]=[C:2]1[NH:3][C:4](=[O:6])[C:5](=[CH:8][C:10]2[CH:22]=[CH:21][C:13]([O:14][CH2:15][CH2:16][CH2:17][C:18]([OH:20])=[O:19])=[CH:12][CH:11]=2)[S:1]1

참가 물질

5

반응물 3

HCID 5437ThiazolidinedioneHCID 517045Sodium AcetateHCID 35191904-(4-formylphenoxy)butanoic Acid

생성물 1

HCID 76545899HCID 76545899, 화합물수율 32.3%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Thiazolidine-2,4-dione (3.55 g, 27.6 mmol), 4-(4-formylphenoxy)butyric acid (5.74 g, 27.6 mmol), anhydrous sodium acetate (11.3 g, 138 mmol) and acetic acid (100 mL) was refluxed for 16 h. After cooling, the mixture was filtered and washed with acetic acid and water. Drying in vacuo afforded 2.74 g (32%) of 4-[4-(2,4-dioxothiazolidin-5-ylidenemethyl)phenoxy]butyric acid as a solid.

후처리

  1. temperatureAfter cooling
  2. filtrationthe mixture was filtered
  3. washwashed with acetic acid and water
  4. customDrying in vacuo

출처 및 근거

ORD 기록
ord-d0a2eccdb8d84dcdac3babf420c28868
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07879893B2

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