Ammonium Chloride → methyl 4-(2H-tetrazol-5-ylmethoxy)benzoate

HRID 1361022노트

반응식

HRID 1361022 반응식
[C:1]([CH2:3][O:4][C:5]1[CH:14]=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][CH:6]=1)#[N:2].[N-:15]=[N+:16]=[N-:17].[Na+].[Cl-].[NH4+]>CN(C=O)C>[N:2]1[NH:15][N:16]=[N:17][C:1]=1[CH2:3][O:4][C:5]1[CH:14]=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][CH:6]=1

참가 물질

5

반응물 3

HCID 25517Ammonium ChlorideHCID 33557Sodium AzideHCID 594916Methyl 4-(cyanomethoxy)benzoate

생성물 1

HCID 2991808methyl 4-(2H-tetrazol-5-ylmethoxy)benzoate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of methyl 4-cyanomethyloxybenzoate (53.5 g, 0.20 mol), sodium azide (16.9 g, 0.26 mol) and ammonium chloride (13.9 g, 0.26 mol) in DMF 1000 (mL) was refluxed overnight under N2. After cooling, the mixture was concentrated in vacuo. The residue was suspended in cold water and extracted with ethyl acetate. The combined organic phases were washed with brine, dried over Na2SO4 and concentrated in vacuo, to afford methyl 4-(2H-tetrazol-5-ylmethoxy)benzoate. This compound was used as such in the following step.

후처리

  1. temperaturewas refluxed overnight under N2
  2. temperatureAfter cooling
  3. concentrationthe mixture was concentrated in vacuo
  4. extractionextracted with ethyl acetate
  5. washThe combined organic phases were washed with brine
  6. dry with materialdried over Na2SO4
  7. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-80713e3aee4d41a9b36d121e08a4b094
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07879893B2

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