m-Chloroperbenzoic acid → Formic Acid 4-fluoro-3,5-dimethyl-phenyl ester

HRID 1361068노트

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HRID 1361068 반응식
[F:1][C:2]1[C:9]([CH3:10])=[CH:8][C:5](C=O)=[CH:4][C:3]=1[CH3:11].C1C=C(Cl)C=C([C:19]([O:21]O)=[O:20])C=1>C(Cl)Cl>[F:1][C:2]1[C:3]([CH3:11])=[CH:4][C:5]([O:21][CH:19]=[O:20])=[CH:8][C:9]=1[CH3:10]

참가 물질

4

반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 120407104-Fluoro-3,5-dimethylbenzaldehyde

생성물 1

HCID 59775190Formic Acid 4-fluoro-3,5-dimethyl-phenyl ester

시약·촉매·용매 1

HCID 6344Dichloromethane용매

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온도
25 °C

실험 절차

To a solution of 4-fluoro-3,5-dimethyl-benzaldehyde (1.0 g, 6.4 mmol) in 20 mL DCM was added mCPBA (1.2 g, 7.6 mmol) at 25° C. After being stirred for 20 h at 25° C., the reaction was quenched by the addition of 40 mL of 5% aqueous potassium carbonate. The mixture was extracted DCM (3×30 mL) and the combined DCM layer was washed with brine (2×30 mL). The solution was dried over Na2SO4 before being concentrated under reduced pressure. The crude product was used directly in the next reaction without further purification.

후처리

  1. customthe reaction was quenched by the addition of 40 mL of 5% aqueous potassium carbonate
  2. extractionThe mixture was extracted DCM (3×30 mL)
  3. washthe combined DCM layer was washed with brine (2×30 mL)
  4. dry with materialThe solution was dried over Na2SO4
  5. concentrationbefore being concentrated under reduced pressure
  6. customThe crude product was used directly in the next reaction without further purification

출처 및 근거

ORD 기록
ord-e3a4f3bddc1644fea1604bc7bf43a7f1
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07879911B2

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