m-Chloroperbenzoic acid → 1-(4-fluorophenyl)-1H-pyrazolo[4,3-c]pyridine 5-oxide

HRID 1361156노트

반응식

HRID 1361156 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[CH:15]=[CH:14][N:13]=[CH:12][C:11]=3[CH:10]=[N:9]2)=[CH:4][CH:3]=1.ClC1C=CC=C(C(OO)=[O:25])C=1>ClCCl.CCOC(C)=O.O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:16]3[CH:15]=[CH:14][N+:13]([O-:25])=[CH:12][C:11]=3[CH:10]=[N:9]2)=[CH:6][CH:7]=1

참가 물질

6

반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 592783571-(4-fluorophenyl)-1H-pyrazolo[4,3-c]pyridine

생성물 1

HCID 580842441-(4-fluorophenyl)-1H-pyrazolo[4,3-c]pyridine 5-oxide

시약·촉매·용매 3

HCID 962Water용매HCID 6344Dichloromethane용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 1-(4-fluorophenyl)-1H-pyrazolo[4,3-c]pyridine (0.920 g, 4.31 mmol) in dichloromethane (50 mL) was added 65% m-chloroperbenzoic acid (1.26 g, 4.75 mmol). After 2 hours, the mixture was diluted with EtOAc and water. The organic layer was washed with saturated aqueous NaHCO3, brine, dried over sodium sulfate, filter and concentrated to afford 1-(4-fluorophenyl)-1H-pyrazolo[4,3-c]pyridine 5-oxide.

후처리

  1. washThe organic layer was washed with saturated aqueous NaHCO3, brine
  2. dry with materialdried over sodium sulfate
  3. filtrationfilter
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-e0149687d5f642c1a6544be83a0d99d3
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07879873B2

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