Triacetoxyperiodinane → 4-(Trifluoromethyl)cyclohexanone

HRID 1361290

반응식

HRID 1361290 반응식
[F:1][C:2]([F:11])([F:10])[CH:3]1[CH2:8][CH2:7][CH:6]([OH:9])[CH2:5][CH2:4]1.CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O>C(Cl)Cl>[F:1][C:2]([F:10])([F:11])[CH:3]1[CH2:8][CH2:7][C:6](=[O:9])[CH2:5][CH2:4]1

참가 물질

4

반응물 2

HCID 159087TriacetoxyperiodinaneHCID 27797654-(Trifluoromethyl)cyclohexan-1-ol

생성물 1

HCID 27774914-(Trifluoromethyl)cyclohexanone수율 94.7%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 4-Trifluoromethylcyclohexanol (4.5 g, 26.7 mmol) in DCM (100 ml) was added Dess-Martin periodinane (13.6 g, 32 mmol), and stirred at rt for 2 h. After the reaction finished, the reaction mixture was concentrated in vacuo, sodium thiosulfate aqueous solution and diethylether were added and stirred at rt for 30 min, and extracted with diethylether. The organic layer was dried over MgSO4, concentrated in vacuo at rt to give the title compound (4.2 g, 94.6%).

후처리

  1. concentrationthe reaction mixture was concentrated in vacuo, sodium thiosulfate aqueous solution and diethylether
  2. additionwere added
  3. stirringstirred at rt for 30 min
  4. extractionextracted with diethylether
  5. dry with materialThe organic layer was dried over MgSO4
  6. concentrationconcentrated in vacuo at rt

출처 및 근거

ORD 기록
ord-9a2d600bc0624045b5fc87d95f3ff87c
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07879852B2

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