Piperazine → 3-Chloro-4-(piperazin-1-yl)benzonitrile

HRID 1361441

반응식

HRID 1361441 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1F)[C:5]#[N:6].[NH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1)[C:5]#[N:6]

참가 물질

5

반응물 3

HCID 4837PiperazineHCID 11430Potassium CarbonateHCID 1455253-Chloro-4-fluorobenzonitrile

생성물 1

HCID 193671133-Chloro-4-(piperazin-1-yl)benzonitrile

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A solution of 3-chloro-4-fluoro-benzonitrile (236 mg, 1.52 mmoles), piperazine (784 mg, 9.1 mmoles) and potassium carbonate (276 mg, 2 mmoles) in acetonitrile (5 mL) was heated to 100° C. overnight. The mixture was cooled, filtered and the filtrate concentrated under reduced pressure. The crude residue was purified by column chromatography (silica gel, 0-5% 2N methanolic ammonia in DCM) to provide the title compound. MS(APCI+) m/z 222 (M+H)+.

후처리

  1. temperatureThe mixture was cooled
  2. filtrationfiltered
  3. concentrationthe filtrate concentrated under reduced pressure
  4. customThe crude residue was purified by column chromatography (silica gel, 0-5% 2N methanolic ammonia in DCM)

출처 및 근거

ORD 기록
ord-140b23027ee3474aaa6d1ed76ba30d60
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07880001B2

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