1-Methyl-4-[2-nitro-4-(trifluoromethyl)phenyl]piperazine → 2-(4-Methylpiperazin-1-yl)-5-(trifluoromethyl)aniline

HRID 1361588노트

반응식

HRID 1361588 반응식
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][C:9]=2[N+:18]([O-])=O)[CH2:4][CH2:3]1>CO.[Pd]>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:15])[F:16])=[CH:10][C:9]=2[NH2:18])[CH2:6][CH2:7]1

참가 물질

4

반응물 1

HCID 28607241-Methyl-4-[2-nitro-4-(trifluoromethyl)phenyl]piperazine

생성물 1

HCID 6932882-(4-Methylpiperazin-1-yl)-5-(trifluoromethyl)aniline

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To 1-Methyl-4-(2-nitro-4-trifluoromethyl-phenyl)-piperazine (1.46 g, 5.05 mmol) in dry MeOH (50 mL) was added Pd/C (10%, 535 mg). H2 gas was bubbled through the solution at room temperature overnight with vigorous stirring. The reaction mixture was filtered through celite to provide, after concentration, the desired product as a white solid. MS (M+H)+=260; Calc'd 259.28 for C12H16F3N3.

후처리

  1. customH2 gas was bubbled through the solution at room temperature overnight with vigorous stirring
  2. filtrationThe reaction mixture was filtered through celite
  3. customto provide
  4. concentrationafter concentration

출처 및 근거

ORD 기록
ord-964508dd143b4f2792d6daa4671bb2dc
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07880000B2

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