HCID 7269394, 화합물 → Ethyl 3-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]propanoate

HRID 1361912노트

반응식

HRID 1361912 반응식
[CH3:1][C:2]1([CH3:14])[O:6][C@H:5](/[CH:7]=[CH:8]/[C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH2:4][O:3]1>[Pd].CO>[CH3:1][C:2]1([CH3:14])[O:6][C@H:5]([CH2:7][CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH2:4][O:3]1

참가 물질

4

반응물 1

HCID 7269394HCID 7269394, 화합물

생성물 1

HCID 22831642Ethyl 3-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]propanoate

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a methanol (200 mL) solution of ethyl (2E)-3-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]acrylate (15.3 g, 76.7 mmol) was added 10% palladium on carbon (1.5 g). The reaction mixture was stirred under an atmosphere of hydrogen overnight. The catalyst was removed by filtration, and the solvent was removed in vacuo. Chromatography over silica afforded the title compound. 1H NMR (400 MHz, CDCl3): δ 4.05-4.15 (m, 2H), 4.02-4.04 (m, 2H), 3.52-3.55 (m, 1H), 2.30-2.47 (m, 2H), 1.83-1.90 (m, 2H), 1.33 (s, 3H), 1.26 (s, 3H), 1.21 (t, J=6.8 Hz, 3H).

후처리

  1. customThe catalyst was removed by filtration
  2. customthe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-abb701668b8f438ea180783a7c4649c6
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07880014B2

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