Skatole → 1,2,7-trimethyl-1H-indole

반응식

[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][CH:7]=[CH:6][C:5]=2[CH3:11].[CH3:12]C1C2C(=CC=CC=2)NC=1>>[CH3:12][N:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][C:5]=2[CH3:11])[CH:10]=[C:2]1[CH3:1]

참가 물질

반응물 2

HCID 6736Skatole

HCID 2598352,7-dimethyl-1H-indole

생성물 1

HCID 221390881,2,7-trimethyl-1H-indole수율 87%

실험 절차

According to the procedure of Preparation 13 (a), except substituting 2,7-dimethylindole for the 3-methylindole, the title compound (960 mg, 87%) was obtained as an oil: MS (ES) m/e 160.2 (M+H)+.

출처 및 근거

ORD 기록: ord-68cfdc1a1a444149be140d705891f560
출처 데이터셋: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07879872B2

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