Piperidine → 5-Bromo-3-piperidin-1-ylmethyl-pyridin-2-ylamine

HRID 1362097

반응식

HRID 1362097 반응식
Br.[Br:2][C:3]1[CH:4]=[C:5]([CH2:10]Br)[C:6]([NH2:9])=[N:7][CH:8]=1.[NH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1>CC#N.CCOCC>[Br:2][C:3]1[CH:4]=[C:5]([CH2:10][N:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)[C:6]([NH2:9])=[N:7][CH:8]=1

참가 물질

5

반응물 2

HCID 8082PiperidineHCID 534200525-Bromo-3-(bromomethyl)pyridin-2-amine hydrobromide

생성물 1

HCID 594569835-Bromo-3-piperidin-1-ylmethyl-pyridin-2-ylamine수율 53.5%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 6342Acetonitrile용매

실험 절차

An ice-cold suspension of 5-bromo-3-bromomethyl-pyridin-2-ylamine hydrobromide (10.0 g, 28.8 mmol) in MeCN (100 mL) was treated with piperidine (6.4 mL, 64.8 mmol). After stirring at room temperature for 3.5 h, the mixture was diluted with Et2O (500 mL). The solution was filtered and then concentrated to give the title compound (4.16 g, 53%) as a pale, yellow solid: MS (ESI) m/e 270 (M+H)+.

후처리

  1. filtrationThe solution was filtered
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-7b1adbb30ca24a069da8dc51c1197c74
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07879872B2

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