(3-Bromophenyl)acetic acid → Ethyl 3-(bromophenyl)acetate

반응식

[CH2:1]([O:3][C:4](=[O:13])[CH2:5][C:6]1[CH:11]=[CH:10][C:9](Br)=[CH:8][CH:7]=1)[CH3:2].[Br:14]C1C=C(CC(O)=O)C=CC=1>>[CH2:1]([O:3][C:4](=[O:13])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([Br:14])[CH:7]=1)[CH3:2]

참가 물질

반응물 2

HCID 74653(3-Bromophenyl)acetic acid

HCID 7020609Ethyl 2-(4-bromophenyl)acetate2회

생성물 1

HCID 11470552Ethyl 3-(bromophenyl)acetate

실험 절차

Employing the same general procedure as for the preparation of ethyl(4-bromophenyl)acetate (Compound A), 100 g (463 mmol) of 3-bromophenylacetic acid was converted into the title compound (yellow oil) using 2 g of conc. H2SO4 and 500 ml of ethanol. PMR (CDCl3): δ 1.26 (3H, t, J=7.0 Hz), 3.56 (2H, s), 4.16 (2H, q, J=7.0 Hz), 7.16-7.26 (2H, m), 7.38-7.46 (2H, m).

출처 및 근거

ORD 기록: ord-f9d9123ba1f04c7494e0e6ceb5f56621
출처 데이터셋: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05723666

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