Sodium Azide → HCID 86610160, 화합물

HRID 1363214노트

반응식

HRID 1363214 반응식
CS(O[C@H:6]1[CH2:11][CH2:10][O:9][C@@H:8]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:7]1)(=O)=O.[N-:18]=[N+:19]=[N-:20].[Na+]>CN(C=O)C.C(Cl)Cl>[N:18]([C@@H:6]1[CH2:11][CH2:10][O:9][C@@H:8]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:7]1)=[N+:19]=[N-:20]

참가 물질

5

반응물 2

HCID 33557Sodium AzideHCID 86610159HCID 86610159, 화합물

생성물 1

HCID 86610160HCID 86610160, 화합물수율 78.8%

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 6344Dichloromethane용매

반응 조건

온도
100 °C

실험 절차

A solution of cis-2-phenyl-tetrahydro-2H-pyran-4-yl methanesulfonate (0.8 g) in DMF (10 mL) was treated with sodium azide (0.8 g) and heated at 100° C. for 4 hours. The mixture was diluted with DCM (50 mL) and washed with water and brine. The organic layer was dried and concentrated. Preparative TLC provided 0.5 g of trans-4-azido-2-phenyl-tetrahydro-2H-pyran.

후처리

  1. washwashed with water and brine
  2. customThe organic layer was dried
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-0fc6cc1406d84225bd7c27f840933d4b
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07884109B2

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