Ethyl 3-chloro-4H-thieno[3,2-b]pyrrole-5-carboxylate → HCID 59648579, 화합물

HRID 1363304노트

반응식

HRID 1363304 반응식
Br[C:2]1[C:6]2[NH:7][C:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:9][C:5]=2[O:4][CH:3]=1.[Cl:15]C1C2NC(C(OCC)=O)=CC=2SC=1>CCCCCCC.CCOC(C)=O>[Cl:15][C:2]1[C:6]2[NH:7][C:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:9][C:5]=2[O:4][CH:3]=1

참가 물질

4

반응물 2

HCID 57348924Ethyl 3-chloro-4H-thieno[3,2-b]pyrrole-5-carboxylateHCID 59648581Ethyl 3-bromo-4H-furo[3,2-b]pyrrole-5-carboxylate

생성물 1

HCID 59648579HCID 59648579, 화합물수율 42%

시약·촉매·용매 1

HCID 21899848Ethylacetate heptane용매

실험 절차

The title compound was synthesized from ethyl 3-bromo-4H-furo[3,2-b]pyrrole-5-carboxylate (200 mg, 0.774 mmol) using the conditions to synthesize ethyl 3-chloro-4H-thieno[3,2-b]pyrrole-5-carboxylate. Chromatography (silica gel, heptane/EtOAc) yielded ethyl 3-chloro-4H-furo[3,2-b]pyrrole-5-carboxylate (70 mg, 42% yield).

출처 및 근거

ORD 기록
ord-4b159802e4c2467d91b226eb472f5f8f
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07884124B2

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