Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → (+)-trans-8-(2-Hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-2-(4-trifluoromethyl-phenyl)-chromen-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Methyl 4-(trifluoromethyl)benzoate | HCID 520447 | — |
| 반응물 | (-)-trans-1-[2-Hydroxy-3-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-4,6-dimethoxyphenyl]-1-ethanone | HCID 59318484 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | (+)-trans-8-(2-Hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-2-(4-trifluoromethyl-phenyl)-chromen-4-one | HCID 66933632 | — |
반응 단계
Compound of example 6 (1.5 g, 4.84 mmol) in dry DMF (15 mL) was reacted with methyl 4-trifluoromethylbenzoate (3.27 g, 16.02 mmol) in the presence of NaH (50%, 1.2 g, 25 mmol) as described in example 16, to obtain the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07884127B2 |
| 출처 데이터셋 | uspto-grants-2011_02 |
| ORD ID | ord-910d8171c19b4586b97e24f691c06dc4 |
| 출처 메모 | uspto-grants-2011_02 |