8-(Nitromethyl)-1,4-dioxaspiro[4.5]decan-8-ol → 8-(Aminomethyl)-1,4-dioxaspiro[4.5]decan-8-ol

HRID 1363545

반응식

HRID 1363545 반응식
[N+:1]([CH2:4][C:5]1([OH:15])[CH2:14][CH2:13][C:8]2([O:12][CH2:11][CH2:10][O:9]2)[CH2:7][CH2:6]1)([O-])=O>C(O)C.[OH-].[OH-].[Pd+2]>[NH2:1][CH2:4][C:5]1([OH:15])[CH2:14][CH2:13][C:8]2([O:12][CH2:11][CH2:10][O:9]2)[CH2:7][CH2:6]1

참가 물질

4

반응물 1

HCID 468356938-(Nitromethyl)-1,4-dioxaspiro[4.5]decan-8-ol

생성물 1

HCID 434366478-(Aminomethyl)-1,4-dioxaspiro[4.5]decan-8-ol수율 530.2%

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 702Ethanol용매

실험 절차

A mixture of 8-(nitromethyl)-1,4-dioxaspiro[4.5]decan-8-ol (16.0 g, 13.8 mmol) and 20% palladium hydroxide on carbon (3.2 g) in ethanol (160 mL) was hydrogenated at 50 psi (3.5×105 Pa) for 5 d on a Parr apparatus. The reaction mixture was filtered through CELITE filter agent and the filtrate was concentrated to give 8-(aminomethyl)-1,4-dioxaspiro[4.5]decan-8-ol as a clear oil (13.7 g, 99%) that solidified upon standing overnight.

후처리

  1. filtrationThe reaction mixture was filtered through CELITE
  2. filtrationfilter agent
  3. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-c49b7fac5cc446fe9b1f2a7672548365
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07884207B2

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