Dimethylformamide → Ethyl 7-(3,5-bis(trifluoromethyl)phenoxy)heptanoate

HRID 1363874노트

반응식

HRID 1363874 반응식
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9].[F:13][C:14]([F:27])([F:26])[C:15]1[CH:16]=[C:17]([OH:25])[CH:18]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:20]=1.CN(C)C=O.C(=O)([O-])[O-].[K+].[K+]>O>[F:13][C:14]([F:26])([F:27])[C:15]1[CH:16]=[C:17]([CH:18]=[C:19]([C:21]([F:22])([F:23])[F:24])[CH:20]=1)[O:25][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9]

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 676803,5-Bis(trifluoromethyl)phenolHCID 122490Ethyl 7-bromoheptanoate

생성물 1

HCID 86620562Ethyl 7-(3,5-bis(trifluoromethyl)phenoxy)heptanoate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Ethyl 7-bromoheptanoate and 3,5-bis(trifluoromethyl) phenol were added to dimethylformamide (DMF). The solution was added with potassium carbonate and stirred at room temperature. The solution was added with water and extracted twice with ethyl acetate. After the organic layer was washed three times with water and dried over anhydrous magnesium sulfate, the solvent was removed. The residue was purified by silica gel column chromatography to obtain ethyl 7-(3,5-bis (trifluoromethyl)phenoxy)heptanoate.

후처리

  1. extractionextracted twice with ethyl acetate
  2. washAfter the organic layer was washed three times with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customthe solvent was removed
  5. customThe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-e8e04a83780f4898b380de6ef251f5f6
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07887835B2

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