Pyridine → Methyl 9-[(methanesulfonyl)oxy]nonanoate

HRID 1363876노트

반응식

HRID 1363876 반응식
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([O:12][CH3:13])=[O:11].N1C=CC=CC=1.ClCCl.[CH3:23][S:24](Cl)(=[O:26])=[O:25]>O>[CH3:23][S:24]([O:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([O:12][CH3:13])=[O:11])(=[O:26])=[O:25]

참가 물질

6

반응물 4

HCID 1049PyridineHCID 6344DichloromethaneHCID 31297Methanesulfonyl chlorideHCID 292983Nonanoic acid, 9-hydroxy-, methyl ester

생성물 1

HCID 22939818Methyl 9-[(methanesulfonyl)oxy]nonanoate

시약·촉매·용매 1

HCID 962Water용매

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온도
0 °C

실험 절차

Methyl 9-hydroxynonanoate and pyridine were added to dichloromethane. The solution was stirred at 0° C., added with methanesulfonyl chloride, and further stirred with gradually warming up to room temperature. The solution was added with water, and extracted twice with dichloromethane. The resulting organic layer was washed with 1N hydrochloric acid and saturated sodium hydrogen carbonate. After the organic layer was dried over anhydrous sodium sulfate, the solvent was removed and the residue was purified by silica gel column chromatography to obtain methyl 9-(methanesulfonyloxy)nonanoate.

후처리

  1. stirringfurther stirred
  2. temperaturewith gradually warming up to room temperature
  3. extractionextracted twice with dichloromethane
  4. washThe resulting organic layer was washed with 1N hydrochloric acid and saturated sodium hydrogen carbonate
  5. dry with materialAfter the organic layer was dried over anhydrous sodium sulfate
  6. customthe solvent was removed
  7. customthe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-1250e83c3168489b8043280265ae1f02
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07887835B2

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