Trifluoroacetic acid → HCID 66930841, 화합물

HRID 1364128노트

반응식

HRID 1364128 반응식
[NH2:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH:19]=[C:18]3[C:12]([CH2:13][CH2:14][N:15](C(OC(C)(C)C)=O)[CH2:16][CH2:17]3)=[N:11]2)=[CH:6][CH:5]=1)=[O:3].FC(F)(F)C(O)=O>ClCCl.CO>[N:11]1[N:10]([C:7]2[CH:8]=[CH:9][C:4]([C:2]([NH2:1])=[O:3])=[CH:5][CH:6]=2)[CH:19]=[C:18]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13][C:12]=12

참가 물질

5

반응물 2

HCID 6422Trifluoroacetic acidHCID 669308541,1-Dimethylethyl 2-[4-(aminocarbonyl)phenyl]-4,5,7,8-tetrahydropyrazolo[3,4-d]azepine-6(2H)-carboxylate

생성물 1

HCID 66930841HCID 66930841, 화합물

시약·촉매·용매 2

HCID 887Methanol용매HCID 6344Dichloromethane용매

실험 절차

To a solution of 1,1-dimethylethyl 2-[4-(aminocarbonyl)phenyl]-4,5,7,8-tetrahydropyrazolo[3,4-d]azepine-6(2H)-carboxylate (may be prepared as described in Description 36) (167 mg, 0.47 mmol) in dichloromethane (14 ml) was added trifluoroacetic acid (7 ml). The resulting mixture was stirred at room temperature, under argon, for 2 hours and then diluted with methanol. Reaction was purified by SCX, eluting with methanol and then 2M ammonia/methanol. The basic fractions were combined and solvent evaporated in vacuo to afford the title compound (D37). MS (ES+) m/e 257 [M+H]+.

후처리

  1. customReaction
  2. customwas purified by SCX
  3. washeluting with methanol
  4. customsolvent evaporated in vacuo

출처 및 근거

ORD 기록
ord-3f67fc08d3734df4b3d5019f6964dd3f
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07888347B2

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