3-(Benzenesulfonyl)propanoic acid → HCID 57954722, 화합물

반응식

[NH:1]1[CH2:6][CH2:5][CH:4]([C@H:7]([NH:18][S@](C(C)(C)C)=O)[CH2:8][C:9]2[CH:14]=[C:13]([F:15])[C:12]([F:16])=[CH:11][C:10]=2[F:17])[CH2:3][CH2:2]1.[C:25]1([S:31]([CH2:34][CH2:35][C:36](O)=[O:37])(=[O:33])=[O:32])[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[NH2:18][C@@H:7]([CH:4]1[CH2:3][CH2:2][N:1]([C:36](=[O:37])[CH2:35][CH2:34][S:31]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)(=[O:33])=[O:32])[CH2:6][CH2:5]1)[CH2:8][C:9]1[CH:14]=[C:13]([F:15])[C:12]([F:16])=[CH:11][C:10]=1[F:17]

참가 물질

반응물 2

HCID 5552523-(Benzenesulfonyl)propanoic acid

HCID 57954726HCID 57954726, 화합물

생성물 1

HCID 57954722HCID 57954722, 화합물

실험 절차

The title compound is prepared analogously as described in example G1 using (S)-2-methyl-propane-2-sulfinic acid [(R)-1-piperidin-4-yl-2-(2,4,5-trifluoro-phenyl)-ethyl]-amide instead of 3-exo-[(R)-1-((S)-2-methyl-propane-2-sulfinylamino)-2-(2,4,5-trifluoro-phenyl)-ethyl]-8-aza-bicyclo[3.2.1]octane and 3-benzenesulfonyl-propionic acid instead of N-acetyl-L-alanine.

출처 및 근거

ORD 기록: ord-d7d03a4719964513b642a42b79eb1544
출처 데이터셋: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07888351B2

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