Dichlorodimethylsilane → 7-Mercapto-3,4-dihydro-2H-isoquinolin-1-one

HRID 1364189노트

반응식

HRID 1364189 반응식
Cl[Si](Cl)(C)C.[O:6]=[C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([S:17](Cl)(=O)=O)[CH:15]=2)[CH2:10][CH2:9][NH:8]1.CN1CCN(C)C1=O>ClCCCl.[Zn]>[SH:17][C:14]1[CH:15]=[C:16]2[C:11]([CH2:10][CH2:9][NH:8][C:7]2=[O:6])=[CH:12][CH:13]=1

참가 물질

6

반응물 3

HCID 6398DichlorodimethylsilaneHCID 66611,3-Dimethyl-2-imidazolidinoneHCID 180713741-Oxo-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride

생성물 1

HCID 642254267-Mercapto-3,4-dihydro-2H-isoquinolin-1-one

시약·촉매·용매 2

HCID 23994Zinc촉매HCID 111,2-Dichloroethane용매2회

실험 절차

To a zinc powder (2.79 g, 42.7 mmol) and Dichlorodimethylsilane (5.15 mL, 42.7 mmol) in DCE (45 mL) is added a solution of 1-Oxo-1,2,3,4-tetrahydro-isoquinoline-7-sulfonyl chloride (3 g, 12.2 mmol) and 1,3-dimethylimidazolidin-2-one (3.96 mL, 36.6 mmol) in DCE (5 mL). After stirring at rt during 2 h, the mixture is concentrated.

후처리

  1. concentrationthe mixture is concentrated

출처 및 근거

ORD 기록
ord-0333231d9de44f7b930d83cd99972a19
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07888351B2

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