Cyanoacetic acid → 2-Cyano-N-(2-methyl-6-nitrophenyl)acetamide
반응식
[CH3:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([N+:9]([O-:11])=[O:10])[C:3]=1[NH2:4].[C:12]([CH2:14][C:15](O)=[O:16])#[N:13].P(Cl)(Cl)(Cl)(Cl)Cl>C1C=CC=CC=1>[C:12]([CH2:14][C:15]([NH:4][C:3]1[C:5]([N+:9]([O-:11])=[O:10])=[CH:6][CH:7]=[CH:8][C:2]=1[CH3:1])=[O:16])#[N:13]참가 물질
5
반응 조건
- 온도
- 60 °C
실험 절차
To a solution of 2-methyl-6-nitroaniline (25 g, 164.3 mmol) in benzene (200 mL) were added cyanoacetic acid (14.5 g, 170.46 mmol) and PCl5 (35 g, 168 mmol). The reaction mixture was heated at 60° C. for 7 h. After cooling to rt, the reaction mixture was filtered and the solid was washed with benzene and water. The solid was dried under reduced pressure to afford the title acetamide (24 g, 109 mmol) as a yellow solid.
후처리
- temperatureAfter cooling to rt
- filtrationthe reaction mixture was filtered
- washthe solid was washed with benzene and water
- customThe solid was dried under reduced pressure
출처 및 근거
- ORD 기록
- ord-a5da6707aa424878a787301357002749
- 출처 데이터셋
- uspto-grants-2011_02
- 특허 번호
- US07888359B2
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