참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 1-(2-Bromo-4-chlorophenyl)ethanone | HCID 4712644 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 2-(4-Chlorophenyl)-2-oxoethyl acetate | HCID 587254 | 90.1% |
반응 단계
To a cooled (4° C.) and stirred solution of 2-bromo-4-chloroacetophenone (5.0 g, 21.41 mmol) and glacial acetic acid (2.8 mL, 49.25 mmol) in acetonitrile was added triethylamine (6.1 mL, 44.97 mmol). The reaction mixture was warmed to room temperature, than refluxed for 3 hours. The reaction mixture was extracted with ether, acetate, washed with 1N hydrochloric acid, brine, dried, and concentrated to yield 4.1 g of acetic acid 2-(4-chlorophenyl)-2-oxo-ethyl ester.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07888366B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_02 |
|---|
| ORD ID | ord-519aa66d13344181be664316a80c9309 |
|---|
| 출처 메모 | uspto-grants-2011_02 |
|---|
