4-Fluoromandelic acid → 1-(4-Fluorophenyl)ethane-1,2-diol

HRID 1364482노트

반응식

HRID 1364482 반응식
[F:1][C:2]1[CH:12]=[CH:11][C:5]([CH:6]([OH:10])[C:7](O)=[O:8])=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:6]([OH:10])[CH2:7][OH:8])=[CH:11][CH:12]=1

참가 물질

4

반응물 2

HCID 980684-Fluoromandelic acidHCID 21226445Aluminium lithium hydride

생성물 1

HCID 114125091-(4-Fluorophenyl)ethane-1,2-diol수율 94.8%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a stirred solution of 4-fluoromandelic acid (1.0 g, 5.88 mmol) in tetrahydrofuran was added lithium aluminum hydride (0.47 g, 12.34 mmol). The reaction mixture was refluxed for 1.5 hours. The reaction mixture was quenched with sat. ammonium chloride solution, filtered, concentrated to yield 0.87 g of 1-(4-fluorophenyl)ethane-1,2-diol.

후처리

  1. temperatureThe reaction mixture was refluxed for 1.5 hours
  2. customThe reaction mixture was quenched with sat. ammonium chloride solution
  3. filtrationfiltered
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-7ed6ebe1518749a3827ce5862c546dec
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07888366B2

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