Nitric Acid → 2-(2,5-Dimethoxy-4-nitrophenyl)acetic acid

HRID 1364551

반응식

HRID 1364551 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[CH2:11][C:12]([OH:14])=[O:13].[N+:15]([O-])([OH:17])=[O:16]>C(O)(=O)C.O>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([N+:15]([O-:17])=[O:16])[C:6]([O:9][CH3:10])=[CH:5][C:4]=1[CH2:11][C:12]([OH:14])=[O:13]

참가 물질

5

반응물 2

HCID 944Nitric AcidHCID 744692,5-Dimethoxyphenylacetic acid

생성물 1

HCID 123157582-(2,5-Dimethoxy-4-nitrophenyl)acetic acid수율 69%

시약·촉매·용매 2

HCID 176Acetic Acid용매2회HCID 962Water용매

실험 절차

A solution of of 2,5-dimethoxyphenylacetic acid (1.00 g, 5.10 mmol) in 10 mL of acetic acid was added 6.5 mL of 1.0M HNO3 in acetic acid. The reaction was stirred at ambient temperature for 10 min, and diluted with 75 mL of water. The yellow precipitate was collected and washed with water (3×10 mL), then dried on the filter. Recrystallization from 20 mL of 2-propanol gave 846 mg (69%) of the titled compound as fine yellow crystals.

후처리

  1. customThe yellow precipitate was collected
  2. washwashed with water (3×10 mL)
  3. customdried on the filter
  4. customRecrystallization from 20 mL of 2-propanol

출처 및 근거

ORD 기록
ord-1b6198da01a148ad9b38abc99bb3f0bf
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07888374B2

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