Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic acid → 4-(aminomethyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | 4-Chloro-3-(pyridin-2-yl)aniline | HCID 40151925 | — |
| 반응물 | BOC-4-(aminomethyl)benzoic acid | HCID 66878017 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-(aminomethyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide | HCID 66877992 | — |
반응 단계
Procedure G was used to couple BOC-4-(aminomethyl)benzoic acid (48 mg) with 4-chloro-3-(pyridin-2-yl)aniline (35 mg). The crude reaction mixture was treated with TFA (1 mL) containing trace amounts of water for 1 h. The reaction mixture was concentrated to yield 4-(aminomethyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07888364B2 |
| 출처 데이터셋 | uspto-grants-2011_02 |
| ORD ID | ord-61a403f8baa349dc8a2c4cba6315484b |
| 출처 메모 | uspto-grants-2011_02 |