N-(Phenylmethyl)thiourea → N-benzyl-4-(pyridin-2-yl)thiazol-2-amine

HRID 1364647

반응식

HRID 1364647 반응식
Br.Br[CH2:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][N:7]=1)=O.[CH2:12]([NH:19][C:20]([NH2:22])=[S:21])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C(O)C>[CH2:12]([NH:19][C:20]1[S:21][CH:3]=[C:4]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][N:7]=2)[N:22]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

4

반응물 2

HCID 737375N-(Phenylmethyl)thioureaHCID 27762312-Bromo-1-(2-pyridinyl)-1-ethanone hydrobromide

생성물 1

HCID 2902584N-benzyl-4-(pyridin-2-yl)thiazol-2-amine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 2-(Bromoacetyl)pyridine hydrobromide (100 mg, 0.36 mmol) in ethanol (2 mL) was treated with 1-benzyl-2-thiourea (90 mg, 0.54 mmol). The resulting yellow solution was concentrated, and the crude residue was purified on reverse phase HPLC to produce N-benzyl-4-(pyridin-2-yl)thiazol-2-amine.

후처리

  1. concentrationThe resulting yellow solution was concentrated
  2. customthe crude residue was purified on reverse phase HPLC

출처 및 근거

ORD 기록
ord-17266527468542159406903cc806f76b
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07888364B2

연결된 노트

불러오는 중…