Chlorosuccinimide → N-benzyl-5-chloro-4-(pyridin-2-yl)thiazol-2-amine

HRID 1364648

반응식

HRID 1364648 반응식
[CH2:1]([NH:8][C:9]1[S:10][CH:11]=[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=2)[N:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:20]N1C(=O)CCC1=O>CN(C=O)C>[CH2:1]([NH:8][C:9]1[S:10][C:11]([Cl:20])=[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=2)[N:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 31398ChlorosuccinimideHCID 2902584N-benzyl-4-(pyridin-2-yl)thiazol-2-amine

생성물 1

HCID 58614641N-benzyl-5-chloro-4-(pyridin-2-yl)thiazol-2-amine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of N-benzyl-4-(pyridin-2-yl)thiazol-2-amine (60 mg, 0.23 mmol) in DMF (2 mL) was cooled to 0° C. and treated with N-chlorosuccinimide (33 mg, 0.25 mmol), and the reaction mixture was allowed to warm to room temperature. The solvent was evaporated, and the product was purified on reverse phase HPLC to produce N-benzyl-5-chloro-4-(pyridin-2-yl)thiazol-2-amine. MS (Q1) 302.2 (M)+.

후처리

  1. customThe solvent was evaporated
  2. customthe product was purified on reverse phase HPLC

출처 및 근거

ORD 기록
ord-8233f7d92a354f708951ac2c74f968d1
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07888364B2

연결된 노트

불러오는 중…