Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Anhydride → 6-Bromo-2-methyl-4H-3,1-benzoxazin-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 반응물 | 2-Amino-5-bromobenzoic acid | HCID 79858 | — |
| 생성물 | 6-Bromo-2-methyl-4H-3,1-benzoxazin-4-one | HCID 2797142 | 85% |
반응 단계
2-Amino-5-bromobenzoic acid (25 g, 116 mmol) was added in portions to acetic anhydride (150 mL) giving a slightly exothermic reaction to 30° C. The suspension was heated at reflux for 2 h. The product crystallized spontaneously upon cooling. After stirring in ice for 30 min, the crystals were filtered off and washed twice with heptane. The crystals were thoroughly dried at 0.1 mbar/50° C. One obtained 22.4 g (85%) of beige crystals. MS: m/z=239/241 (M).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07728142B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-c8e59a2becb04486bdd9575972ab5d27 |
| 출처 메모 | uspto-grants-2010_06 |