HCID 23079541, 화합물 → 3-Benzyloxy-5-bromo-4-formyl-1-isopropyl-1H-pyrazole

HRID 1365048노트

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HRID 1365048 반응식
[CH2:1]([O:8][C:9]1[C:13]([CH2:14][OH:15])=[C:12]([Br:16])[N:11]([CH:17]([CH3:19])[CH3:18])[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>ClCCl.[O-2].[O-2].[Mn+4]>[CH2:1]([O:8][C:9]1[C:13]([CH:14]=[O:15])=[C:12]([Br:16])[N:11]([CH:17]([CH3:19])[CH3:18])[N:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 1

HCID 23079541HCID 23079541, 화합물

생성물 1

HCID 230795443-Benzyloxy-5-bromo-4-formyl-1-isopropyl-1H-pyrazole수율 90.6%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매

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온도
50 °C

실험 절차

3-Benzyloxy-5-bromo-4-hydroxymethyl-1-isopropyl-1H-pyrazole (3.0 g) was dissolved in dichloromethane (30 mL), and manganese dioxide (4 g) was added to the stirred solution at room temperature. The mixture was stirred at 50° C. for 1 hour. After the insoluble material was removed by filtration, the filtrate was concentrated under reduced pressure to give the title compound (2.7 g).

후처리

  1. customAfter the insoluble material was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-73019fcc02c2490abb30309ac51904c8
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07888487B2

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