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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1365417생성일: 2026년 10월 26일

2-Aminopyrimidine-5-boronic acid, pinacol ester → 2-(4-((2-(2-Aminopyrimidin-5-yl)-4-morpholinothieno[2,3-d]pyrimidin-6-yl)methyl)piperazin-1-yl)ethanol

https://huagongshe.com/reaction/1365417

반응식

참여 물질

역할이름HCID투입량
반응물2-Aminopyrimidine-5-boronic acid, pinacol esterHCID 17750212—
반응물2-(4-((2-Chloro-4-morpholinothieno[2,3-d]pyrimidin-6-yl)methyl)piperazin-1-yl)ethanolHCID 58233992—
생성물2-(4-((2-(2-Aminopyrimidin-5-yl)-4-morpholinothieno[2,3-d]pyrimidin-6-yl)methyl)piperazin-1-yl)ethanolHCID 58233900—

반응 단계

2-(4-((2-chloro-4-morpholinothieno[2,3-d]pyrimidin-6-yl)methyl)piperazin-1-yl)ethanol (175 mg) was utilized in a Suzuki coupling with 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine according to General Procedure Suzuki to provide 385 (20 mg) after reverse phase HPLC purification. MS (Q1) 457 (M)+

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07888352B2
출처 데이터셋uspto-grants-2011_02
ORD IDord-f283d1cf86354df6aa6f20e44d000e08
출처 메모uspto-grants-2011_02