10-Undecen-1-ol → 1-Undecene, 11-fluoro-

HRID 1365576

반응식

HRID 1365576 반응식
[CH2:1](O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH:10]=[CH2:11].C(N(C(F)([F:26])C1C=CC=C(C)C=1)CC)C>CCCCCCC>[F:26][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH:10]=[CH2:11]

참가 물질

4

반응물 2

HCID 818510-Undecen-1-olHCID 11820531N,N-Diethyl-alpha,alpha-difluoro-3-methylbenzylamine

생성물 1

HCID 680461-Undecene, 11-fluoro-수율 91%

시약·촉매·용매 1

HCID 8900Heptane용매

실험 절차

In the same apparatus as that used in Example 14, 10-undecene-1-ol (10 mmole; 1.7 g) as the substrate and N,N-diethyl-α,α-difluoro(3-methyl)benzylamine (12 mmole; 2.56 g) as the fluorinating agent were added to heptane as the solvent. While the resultant mixture was stirred at the room temperature, the mixture was irradiated with microwave for 10 minutes. As the product, 1-fluoro-10-undecene was obtained at a yield of 91%.

후처리

  1. customthe mixture was irradiated with microwave for 10 minutes

출처 및 근거

ORD 기록
ord-c8a3fc9beb274f0aac32b7734fb871aa
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07892518B2

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