Sodium Carbonate → (4-Imidazol-1-yl-phenyl)-[5-(1H-pyrazol-4-yl)-imidazo[1,2-a]pyrazin-8-yl]-amine

참여 물질

역할	이름	HCID	투입량
반응물	Sodium Carbonate	HCID 10340	—
반응물	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole	HCID 2774010	—
반응물	(5-Bromo-imidazo[1,2-a]pyrazin-8-yl)-(4-imidazol-1-yl-phenyl)-amine	HCID 59023113	—
촉매	HCID 178418397	HCID 178418397	—
용매	1,4-dioxane N,N-dimethylformamide	HCID 21712069	—
생성물	Ammonia	HCID 222	—
생성물	(4-Imidazol-1-yl-phenyl)-[5-(1H-pyrazol-4-yl)-imidazo[1,2-a]pyrazin-8-yl]-amine	HCID 59023138	110.6%

반응 단계

In the same way as described for Compound 178, step 4, using (5-bromo-imidazo[1,2-a]pyrazin-8-yl)-(4-imidazol-1-yl-phenyl)-amine (49.8 mg, 0.14 mmol), 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole (54.4 mg, 0.280 mmol), Pd(PPh3)4 (39.1 mg, 0.0338 mmol) and 1.5 M Na2CO3 (0.748 mL, 1.12 mmol) in 2:1 DMF-dioxane (1.5 mL). Purification by Isolute Flash SiII cartridge chromatography eluting with 98:2 DCM:NH3 (7M in MeOH), followed by 97:3 DCM:NH3 (7M in MeOH) and 95:5 DCM:NH3 (7M in MeOH) affords the title compound as a white solid (26.5 mg, 55%). LCMS: Rt 1.75 min (96%), m/z (APCI) 343 (M+H)+; 1H-NMR (400 MHz, d6-DMSO) δ (ppm) 7.13 (1H, s), 7.63 (2H, d), 7.67 (1H, s), 7.73 (1H, s), 7.79 (1H, s), 8.09 (1H, br s), 8.18 (1H, s), 8.22 (1H, s), 8.27 (2H, d), 8.43 (1H, br s), 9.82 (1H, s), 13.39 (1H, br s).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07893058B2
출처 데이터셋	uspto-grants-2011_02
ORD ID	ord-23dbbad8a3814b8ead35c74d7359edc4
출처 메모	uspto-grants-2011_02