Methanol → 3-Methoxy-4-nitrophenol

HRID 1366287노트

반응식

HRID 1366287 반응식
F[C:2]1[CH:3]=[C:4]([OH:11])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[CH3:12][OH:13]>C1COCC1.O(C)[K]>[CH3:12][O:13][C:2]1[CH:3]=[C:4]([OH:11])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9]

참가 물질

5

반응물 2

HCID 887MethanolHCID 5209483-Fluoro-4-nitrophenol

생성물 1

HCID 129005323-Methoxy-4-nitrophenol

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매HCID 178502595HCID 178502595, 화합물용매

실험 절차

To a solution of 3-Fluoro-4-nitro-phenol (15.7 g, 100 mmol) in THF (300 mL), 30% KOMe in Methanol (49 mL, 210 mmol) is added at 0° C. The mixture is heated to gentle reflux for 18 hours.

후처리

  1. temperatureThe mixture is heated
  2. temperatureto gentle reflux for 18 hours

출처 및 근거

ORD 기록
ord-98ab525c066748608bd4a0e8a73a9c7b
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07893074B2

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