4-Methylpiperazine-1-carbothioamide → 4-[5-Fluoro-2-(4-methyl-piperazin-1-yl)thiazol-4-yl]-benzoic acid methyl ester

HRID 1366302노트

반응식

HRID 1366302 반응식
[CH3:1][O:2][C:3](=[O:15])[C:4]1[CH:9]=[CH:8][C:7]([C:10](=O)[CH:11](Br)[F:12])=[CH:6][CH:5]=1.[CH3:16][N:17]1[CH2:22][CH2:21][N:20]([C:23](=[S:25])[NH2:24])[CH2:19][CH2:18]1>C(O)C>[CH3:1][O:2][C:3](=[O:15])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:24]=[C:23]([N:20]3[CH2:21][CH2:22][N:17]([CH3:16])[CH2:18][CH2:19]3)[S:25][C:11]=2[F:12])=[CH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 21130864-Methylpiperazine-1-carbothioamideHCID 575519704-(2-Bromo-2-fluoro-acetyl)-benzoic acid methyl ester

생성물 1

HCID 575519414-[5-Fluoro-2-(4-methyl-piperazin-1-yl)thiazol-4-yl]-benzoic acid methyl ester수율 74%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

4-(2-Bromo-2-fluoro-acetyl)-benzoic acid methyl ester (1.18 mmol) and 4-methyl-piperazine-1-carbothioic acid amide (1.18 mmol) were dissolved in ethanol (10 mL). The reaction was heated at reflux for 2 h. The reaction was cooled to RT causing the product to precipitate. The product was collected by filtration and washed with cold ethanol. The product was given an aqueous sodium bicarbonate work up to yield the title compound as a colourless oil (74%). MS (ES+) 337 (M+H, 100%).

후처리

  1. temperatureThe reaction was heated
  2. temperatureat reflux for 2 h
  3. customto precipitate
  4. filtrationThe product was collected by filtration
  5. washwashed with cold ethanol

출처 및 근거

ORD 기록
ord-3dcb4c4511a44e1195376256fbdb0135
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07893067B2

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