Methanol → (2S)-2-Amino-1-(1-pyrrolidinyl)-1-butanone

HRID 1366435노트

반응식

HRID 1366435 반응식
[N:1]1([C:6]([C@@H:8]([NH:11]C(=O)OCC2C=CC=CC=2)[CH2:9][CH3:10])=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1.CO>[OH-].[OH-].[Pd+2]>[N:1]1([C:6]([C@@H:8]([NH2:11])[CH2:9][CH3:10])=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 887MethanolHCID 15130882HCID 15130882, 화합물

생성물 1

HCID 58293418(2S)-2-Amino-1-(1-pyrrolidinyl)-1-butanone수율 97%

시약·촉매·용매 1

HCID 9942167Palladium hydroxide촉매

실험 절차

Phenylmethyl [(1S)-1-(1-pyrrolidinylcarbonyl)propyl]carbamate (J. Med. Chem., 1991, 34, 3149-58) was dissolved in methanol (20 mL) (559 mg, 1.9 mmol). Pd(OH)2 (140 mg) was added, and the resulting suspension was stirred under a hydrogen balloon until the deprotection was complete. Filtration of the catalyst and evaporation of the solvent yielded [(1S)-1-(1-pyrrolidinylcarbonyl)propyl]amine (291 mg, 97%).

후처리

  1. filtrationFiltration of the catalyst and evaporation of the solvent

출처 및 근거

ORD 기록
ord-1a17f13c5aa34ec686eaf1c0840c4e4a
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07893056B2

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