Methylamine → 4-((Methylamino)methyl)thiazol-2-amine

반응식

Cl[CH2:2][C:3]1[N:4]=[C:5]([NH2:8])[S:6][CH:7]=1.[CH3:9][NH2:10]>>[CH3:9][NH:10][CH2:2][C:3]1[N:4]=[C:5]([NH2:8])[S:6][CH:7]=1

참가 물질

반응물 2

HCID 6329Methylamine

HCID 732294-Chloromethylthiazol-2-ylamine

생성물 1

HCID 189398714-((Methylamino)methyl)thiazol-2-amine

실험 절차

4-(Chloromethyl)-1,3-thiazol-2-amine (490 mg, 2.65 mmol) was stirred in 40% aqueous methylamine (25 ml) overnight. The reaction mixture was evaporated. The residue was diluted with 95:5 dichloromethane/methanol (25 ml), was dried over sodium sulfate, was filtered and was evaporated to provide 4-[(methylamino)methyl]-1,3-thiazol-2-amine that was used without purification. LCMS: (M+H)+: 144.0.

후처리

customThe reaction mixture was evaporated
additionThe residue was diluted with 95:5 dichloromethane/methanol (25 ml)
dry with materialwas dried over sodium sulfate
filtrationwas filtered
customwas evaporated

출처 및 근거

ORD 기록: ord-bc4cbc615a75492997445548ce2f3fe3
출처 데이터셋: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07893056B2

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