methyl (2R)-1-(N-{[(phenylmethyl)oxy]carbonyl}glycyl)-2-piperidinecarboxylate → (9aR)-octahydro-1H-pyrido(1,2-a)pyrazine-1,4-dione
반응식
C1(COC([NH:11][CH2:12][C:13]([N:15]2[CH2:20][CH2:19][CH2:18][CH2:17][C@@H:16]2[C:21]([O:23]C)=O)=[O:14])=O)C=CC=CC=1>CO>[C:21]1(=[O:23])[NH:11][CH2:12][C:13](=[O:14])[N:15]2[CH2:20][CH2:19][CH2:18][CH2:17][C@H:16]12참가 물질
3
실험 절차
Methyl (2R)-1-(N-{[(phenylmethyl)oxy]carbonyl}glycyl)-2-piperidinecarboxylate (2.029 g, 6.068 mmol) was dissolved in MeOH (30 mL), degassed and placed under argon. 10% Pd/C (610 mg) was added, and the contents were thoroughly degassed and placed under a hydrogen balloon for 3 h. The contents were then degassed, and the Pd/C was removed by filtration through Celite, washing with MeOH. The filtrate was concentrated in vacuo to provide pure (9aR)-tetrahydro-2H-pyrido[1,2-a]pyrazine-1,4(3H,6H)-dione (779 mg, 76%). LCMS: (M+H)+: 169.1.