HCID 66936015, 화합물 → (4Ar,8as)-1-methyldecahydroquinoxaline

HRID 1366660노트

반응식

HRID 1366660 반응식
[CH3:1][N:2]1[C@@H:11]2[C@@H:6]([CH2:7][CH2:8][CH2:9][CH2:10]2)[N:5](C(OCC2C=CC=CC=2)=O)[CH2:4][CH2:3]1>CO>[CH3:1][N:2]1[C@@H:11]2[C@@H:6]([CH2:7][CH2:8][CH2:9][CH2:10]2)[NH:5][CH2:4][CH2:3]1

참가 물질

3

반응물 1

HCID 66936015HCID 66936015, 화합물

생성물 1

HCID 231577(4Ar,8as)-1-methyldecahydroquinoxaline수율 144.8%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Phenylmethyl (4aS,8aR)-4-methyloctahydro-1(2H)-quinoxalinecarboxylate (2.7 g, 9.4 mmol) was dissolved in 140 mL of MeOH, degassed and placed under argon. 10% Pd/C (400 mg) was added, and the contents were thoroughly degassed and placed under a hydrogen balloon for approximately 2 hrs. The contents were then degassed and filtered through Celite, and the Celite pad was washed with DCM and MeOH. After 19.6 mL 1N HCl was added, the resulting filtrate was concentrated in vacuo to provide the hydrochloride salt of (4aR,8aS)-1-methyldecahydroquinoxaline (2.1 g, 100%). LCMS: (M+H)+: 155.1.

후처리

  1. customdegassed
  2. addition10% Pd/C (400 mg) was added
  3. customthe contents were thoroughly degassed
  4. customfor approximately 2 hrs
  5. customThe contents were then degassed
  6. filtrationfiltered through Celite
  7. washthe Celite pad was washed with DCM and MeOH
  8. additionAfter 19.6 mL 1N HCl was added
  9. concentrationthe resulting filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-2207c62860274943abe7e9e2ad90d50e
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07893056B2

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