Methyl 4-(bromomethyl)benzoate → HCID 57637614, 화합물

HRID 1366804노트

반응식

HRID 1366804 반응식
[C:1]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:20]=[CH:19][C:17]([O-:18])=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[Na+].Br[CH2:23][C:24]1[CH:33]=[CH:32][C:27]([C:28]([O:30][CH3:31])=[O:29])=[CH:26][CH:25]=1>CC(C)=O>[C:1]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:15]=[CH:16][C:17]([O:18][CH2:23][C:24]3[CH:33]=[CH:32][C:27]([C:28]([O:30][CH3:31])=[O:29])=[CH:26][CH:25]=3)=[CH:19][CH:20]=2)[CH2:10][CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]

참가 물질

4

반응물 2

HCID 256687Methyl 4-(bromomethyl)benzoateHCID 57637585Sodium 4-(1-BOC-piperazin-4-yl)phenoxide

생성물 1

HCID 57637614HCID 57637614, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

반응 조건

온도
60 °C

실험 절차

Sodium 4-(1-BOC-piperazin-4-yl)phenoxide (1 equivalent) and methyl 4-bromomethylbenzoate (1 equivalent) were combined in dry acetone and heated to reflux at 60° C. for 18 hours. The slurry was filtered and the filtrate was then concentrated to provide the crude methyl 4-[4-(1-BOC-piperazin-4-yl)phenoxymethyl]benzoate, that was used without purification.

후처리

  1. temperatureheated
  2. filtrationThe slurry was filtered
  3. concentrationthe filtrate was then concentrated

출처 및 근거

ORD 기록
ord-f3a436dbe47c46f9804cc512cdc9913e
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07893096B2

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