1-Aminocyclopropanecarbonitrile → HCID 59619335, 화합물

반응식

[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[S:9]([CH:12]1[CH2:16][CH2:15][CH:14]([C:17]([OH:19])=O)[CH2:13]1)(=[O:11])=[O:10].[NH2:20][C:21]1([C:24]#[N:25])[CH2:23][CH2:22]1>>[C:24]([C:21]1([NH:20][C:17]([C@@H:14]2[CH2:15][CH2:16][C@@H:12]([S:9]([C:3]3[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=3[Cl:1])(=[O:10])=[O:11])[CH2:13]2)=[O:19])[CH2:23][CH2:22]1)#[N:25]

참가 물질

반응물 2

HCID 5568881-Aminocyclopropanecarbonitrile

HCID 66918566HCID 66918566, 화합물

생성물 1

HCID 59619335HCID 59619335, 화합물

실험 절차

The title compound was synthesized in analogy to Example 68/69, Step 11, from rac-(1S,3S)-3-(2-chloro-4-fluoro-benzenesulfonyl)-cyclopentanecarboxylic acid and 1-amino-cyclopropanecarbonitrile to afford the desired product as a light yellow oil. MS (EI): 371.0 (M+H)+.

출처 및 근거

ORD 기록: ord-e3b3629413e9498aae8318e58bcb4a53
출처 데이터셋: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07893099B2

반응 노트

불러오는 중…