1-Aminocyclopropanecarbonitrile → HCID 59619362, 화합물

HRID 1367551노트

반응식

C([O:3][C:4]([C@@H:6]1[CH2:10][C@@H:9]([S:11]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=2[Cl:21])(=[O:13])=[O:12])[CH2:8][C@H:7]1[CH2:22][O:23][CH2:24][C:25]1[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[CH:27][CH:26]=1)=O)C.[NH2:33][C:34]1([C:37]#[N:38])[CH2:36][CH2:35]1>>[C:37]([C:34]1([NH:33][C:4]([C@@H:6]2[CH2:10][C@@H:9]([S:11]([C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=3[Cl:21])(=[O:13])=[O:12])[CH2:8][C@H:7]2[CH2:22][O:23][CH2:24][C:25]2[CH:26]=[CH:27][C:28]([O:31][CH3:32])=[CH:29][CH:30]=2)=[O:3])[CH2:36][CH2:35]1)#[N:38]

참가 물질

반응물 2

HCID 5568881-Aminocyclopropanecarbonitrile

HCID 66918459HCID 66918459, 화합물

생성물 1

HCID 59619362HCID 59619362, 화합물

실험 절차

The title compound was prepared in analogy to example 68 step 10 and 11 using (1R,2R,4S)-4-(2-chloro-4-fluoro-benzenesulfonyl)-2-(4-methoxy-benzyloxymethyl)-cyclopentanecarboxylic acid ethyl ester (example 153 step 8) and 1-amino-cyclopropanecarbonitrile. Light yellow oil (80%). MS (EI): 521.2 (M+H)+.

출처 및 근거

ORD 기록: ord-74fc86678823467295ccce9d3a09b6bc
출처 데이터셋: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07893099B2

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