1-Amino-1-cyclopropanecarbonitrile hydrochloride → HCID 59619368, 화합물

반응식

[Br:1][C:2]1[CH:3]=[C:4]([S:8]([C@@H:11]2[CH2:15][C@@H:14]([C:16]([OH:18])=O)[C@H:13]([C:19]([N:21]3[CH2:25][CH2:24][C:23]([F:27])([F:26])[CH2:22]3)=[O:20])[CH2:12]2)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.[CH2:28]1[C:30]([NH2:33])([C:31]#[N:32])[CH2:29]1.Cl>>[C:31]([C:30]1([NH:33][C:16]([C@@H:14]2[CH2:15][C@@H:11]([S:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Br:1])[CH:3]=3)(=[O:10])=[O:9])[CH2:12][C@H:13]2[C:19]([N:21]2[CH2:25][CH2:24][C:23]([F:26])([F:27])[CH2:22]2)=[O:20])=[O:18])[CH2:28][CH2:29]1)#[N:32]

참가 물질

반응물 2

HCID 145863631-Amino-1-cyclopropanecarbonitrile hydrochloride

HCID 66918562HCID 66918562, 화합물

생성물 1

HCID 59619368HCID 59619368, 화합물

실험 절차

The title compound was prepared in analogy to example 117 step 7 using (1R,2R,4S)-4-(3-Bromo-benzenesulfonyl)-2-(3,3-difluoro-pyrrolidine-1-carbonyl)-cyclopentanecarboxylic acid (example 188 step 3) and 1-amino-cyclopropyl cyanic hydrochloride. Light yellow foam (89%). MS (EI): 532.1 (M+H)+.

출처 및 근거

ORD 기록: ord-d2a42d5724964ff6afd0de8a3604b2af
출처 데이터셋: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07893099B2

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