HCID 59619292, 화합물 → HCID 59619359, 화합물

HRID 1367590노트

반응식

HRID 1367590 반응식
[C:1]([C:3]1([NH:6][C:7]([C@H:9]2[CH2:13][C@H:12]([S:14]([C:17]3[CH:22]=[CH:21][C:20](Br)=[CH:19][C:18]=3[C:24]([F:27])([F:26])[F:25])(=[O:16])=[O:15])[CH2:11][C@@H:10]2[O:28][CH:29]2[CH2:33][CH2:32][CH2:31][CH2:30]2)=[O:8])[CH2:5][CH2:4]1)#[N:2].C(C1(NC([C@H]2C[C@H](S(C3C=CC(Br)=CC=3C(F)(F)F)(=O)=O)C[C@@H]2OC2CCOCC2)=O)CC1)#N>>[C:1]([C:3]1([NH:6][C:7]([C@H:9]2[CH2:13][C@H:12]([S:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[C:24]([F:26])([F:25])[F:27])(=[O:16])=[O:15])[CH2:11][C@@H:10]2[O:28][CH:29]2[CH2:33][CH2:32][CH2:31][CH2:30]2)=[O:8])[CH2:4][CH2:5]1)#[N:2]

참가 물질

3

반응물 2

HCID 59619292HCID 59619292, 화합물HCID 59619432HCID 59619432, 화합물

생성물 1

HCID 59619359HCID 59619359, 화합물

실험 절차

The title compound was prepared in analogy to example 175 using (1R,2R,4R) and (1S,2S,4S)-4-(4-bromo-2-trifluoromethyl-benzenesulfonyl)-2-cyclopentyloxy-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amide (example 195) instead of (1R,2R,4R) and (1S,2S,4S)-4-(4-bromo-2-trifluoromethyl-benzenesulfonyl)-2-(tetrahydro-pyran-4-yloxy)-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amide. White solid. MS (EI): 469.2 (M−H)−.

출처 및 근거

ORD 기록
ord-a97912a919524118ab7bd0bf09369819
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07893099B2

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