Oxalyl chloride → 5-(Benzyloxy)pentanoyl chloride

HRID 1367665노트

반응식

HRID 1367665 반응식
[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(Cl)(=O)C([Cl:19])=O>C1C=CC=CC=1>[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([Cl:19])=[O:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 104205755-(Benzyloxy)pentanoic acid

생성물 1

HCID 102631205-(Benzyloxy)pentanoyl chloride

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

To a solution of the acid 29 (4.98 g, 24 mmol) in dry benzene (40 ml), was added oxalyl chloride (2.5 ml, 28.8 mmol, 1.2 equiv) dropwise. A drying tube was placed on the flask and the reaction was stirred for 90 min at room temperature. The reaction was concentrated in vacuo and used directly in the next step: 1H NMR (400 MHz, CDCl3) δ 7.38-7.27 (m, 5H), 4.50 (s, 2H), 3.51-3.40 (t, 3J=6.4 Hz, 2H), 2.95-2.90 (t, 3J=7.2 Hz, 3H), 1.87-1.78 (m, 2H), 1.71-1.63 (m, 2H); 13C NMR (75 MHz, CDCl3) δ 173.958, 138.519, 128.949, 128.787, 128.630, 127.862, 73.197, 69.551, 47.032, 28.618, 22.329.

후처리

  1. customA drying tube was placed on the flask
  2. concentrationThe reaction was concentrated in vacuo

출처 및 근거

ORD 기록
ord-1d18e44234d34735bf07cd7d56a45342
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07893268B2

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