Phenacyl bromide → HCID 178474414, 화합물
반응식
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=O.[C:11]([NH:14][C:15]([NH2:17])=[NH:16])(=[O:13])[CH3:12]>CN(C=O)C.CCOC(C)=O>[C:5]1([C:3]2[N:16]=[C:15]([NH:14][C:11](=[O:13])[CH3:12])[NH:17][CH:2]=2)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1참가 물질
5
실험 절차
To a solution of 2.0 g (10 mmol) of 2-bromoacetophenone in DMF (30 mL) was added 3.0 g (29 mmol) 1-acetylguanidine in one portion, the reaction mixture was stirred at rt for 2 days. The reaction mixture was diluted with EtOAc (250 mL) and washed with saturated NH4Cl aq. solution (50 mL). The organic phase was dried over MgSO4 and concentrated under vacuum. The residue was purified by a flash column chromatography eluting with EtOAc to give N-(4-phenyl-1H-imidazol-2-yl)-acetamide. (0.5 g, 24%). LCMS: 203 (M+1)+.
후처리
- washwashed with saturated NH4Cl aq. solution (50 mL)
- dry with materialThe organic phase was dried over MgSO4
- concentrationconcentrated under vacuum
- customThe residue was purified by a flash column chromatography
- washeluting with EtOAc
출처 및 근거
- ORD 기록
- ord-b4bae55fc8414f109c534a56b0c32ed6
- 출처 데이터셋
- uspto-grants-2011_02
- 특허 번호
- US07893267B2
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