Ethyl 3,4-dihydro-6,7-dimethoxy-1-isoquinolinecarboxylate → HCID 20202902, 화합물
반응식
[CH2:1]([O:3][C:4]([C:6]1[C:15]2[C:10](=[CH:11][C:12]([O:18][CH3:19])=[C:13]([O:16][CH3:17])[CH:14]=2)[CH2:9][CH2:8][N:7]=1)=[O:5])[CH3:2]>[Pd]>[CH2:1]([O:3][C:4]([C:6]1[C:15]2[C:10](=[CH:11][C:12]([O:18][CH3:19])=[C:13]([O:16][CH3:17])[CH:14]=2)[CH:9]=[CH:8][N:7]=1)=[O:5])[CH3:2]참가 물질
3
실험 절차
To a refluxing solution of 2.0 g (8.0 mmol) of 6,7-dimethoxy-3,4-dihydro-isoquinoline-1-carboxylic acid ethyl ester was added to 2.0 g of 10% Pd—C. After 12 h at reflux, the reaction mixture was cooled, filtered through celite, and evaporated under reduced pressure to provide 2.0 g (98%) of 6,7-dimethoxy-isoquinoline-1-carboxylic acid ethyl ester. LCMS: 262 (M+1)+.
후처리
- temperatureAfter 12 h at reflux
- temperaturethe reaction mixture was cooled
- filtrationfiltered through celite
- customevaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-2ff5c155db1c4ba0bc420650191d1c83
- 출처 데이터셋
- uspto-grants-2011_02
- 특허 번호
- US07893267B2
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